Welcome to Satchi-Fainaro lab!
Multivalency of polymer therapeutics used for the integration of anti-angiogenic therapy with chemotherapy
Tumors consist of three general compartments: tumor cells, tumor vasculature and non-endothelial tumor stroma. The ability of cancers to grow is dependent on the formation and maintenance of new blood vessels from pre-existing vasculature in a complex process referred to as “angiogenesis”. Tumors may remain small and dormant if unable to elicit functional angiogenesis. Consequently, the microvascular endothelial cell, recruited by a tumor, has become a paramount factor in tumor progression and metastases formation making both the tumor cells and their surrounding stroma a target for combined anticancer and anti-angiogenic therapy. Read More »